Spatial distribution of macular pigment estimated by autofluorescence imaging in elderly Japanese individuals
| Autor: | Akira Obana, Mohsen Sharifzadeh, Hiroyuki Sasano, Takahiko Seto, Yuko Gohto, Paul S. Bernstein, Werner Gellermann |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Fundus Oculi Retinal Pigment Epithelium Biology Spatial distribution 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optical coherence tomography Japan Foveal Ophthalmology Macular Pigment medicine Humans Macula Lutea Fluorescein Angiography Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test Parafovea Retinal Mean age General Medicine Middle Aged Autofluorescence chemistry 030221 ophthalmology & optometry Female sense organs 030217 neurology & neurosurgery Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Japanese journal of ophthalmology. 64(2) |
| ISSN: | 1613-2246 |
| Popis: | To determine the spatial distribution types of macular pigment (MP) in elderly Japanese individuals and to consider their origin. Observational case series. Local MP optical density (MPOD) at some eccentricities and MP volume were measured using the MPOD module of a MultiColor Spectralis in 96 pseudophakic eyes of 96 participants (age range, 52–86 years; mean age, 72.8 ± 8.3 years). The MP distribution types were determined from the MP spatial profiles. The retinal thickness (RT) at the foveal center, at both 0.5° and 0.9° eccentricities, and the foveal width were measured using optical coherence tomography. The mean local MPOD at the foveal center was 0.79. Spatial distribution was classified into four types: central peak (24.0%), ring-like (40.6%), intermediate (22.9%), and central dip (12.5%). The ring-like type was the most frequent in these Japanese participants. The central-peak type showed lower MPOD than did the other types in the area outside 0.9°. The ring-like type occurred frequently in eyes with small RT at 0.5° and wider foveal width. A rough contour of the Muller cell cone was found more frequently in the central-dip type than in the other types. The present characteristics of the different distribution patterns could be explained by the hypothesis that MP presents mainly in the Muller cell cone within 0.5° and in Muller cells in the outer and inner plexiform layers in the area outside 0.5°. The anatomic characteristics of Muller cells at the fovea and parafovea likely affect the MP distribution. |
| Databáze: | OpenAIRE |
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