Recent advances in β-l -rhamnosylation
| Autor: | Suvarn S. Kulkarni, Diksha Rai |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Organic & Biomolecular Chemistry. 18:3216-3228 |
| ISSN: | 1477-0539 1477-0520 |
| Popis: | l-Rhamnose forms the key components of important antigenic oligo- and polysaccharides of a variety of pathogens. Obtaining 1,2-cis stereoselectivity in the glycosylation of l-rhamnoside is quite challenging due to the unavailability of neighboring group participation and disfavoring of the anomeric effect and stereoelectronic effect of the substituents on the C-2 axial position. Nevertheless, various methodologies have been developed exploiting diverse pathways for obtaining β-stereoselectivity in the glycosylation of l-rhamnose. This review describes the recent advances in β-l-rhamnosylation and its applications in the total synthesis of β-l-rhamnose-containing biologically important oligosaccharides. |
| Databáze: | OpenAIRE |
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