Global, regional and national quality of life in patients with multiple sclerosis: a global systematic review and meta-analysis
| Autor: | Batool Sadat Hoseini, Ahmad Ghashghaee, Fatemeh Pashazadeh Kan, Mahsa Tohidi Asl, Afsaneh Dehnad, Niloofar Ahmadi, Hossein Hosseinifard, Zahra Hoseinipalangi |
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| Rok vydání: | 2020 |
| Předmět: |
Gerontology
Multiple Sclerosis Activities of daily living Scopus Medicine (miscellaneous) Disease 03 medical and health sciences 0302 clinical medicine Quality of life Surveys and Questionnaires Humans Medicine 030212 general & internal medicine Fatigue Depression (differential diagnoses) Expanded Disability Status Scale Oncology (nursing) business.industry General Medicine Medical–Surgical Nursing Meta-analysis Inclusion and exclusion criteria Disease Progression Quality of Life business 030217 neurology & neurosurgery |
| Zdroj: | BMJ Supportive & Palliative Care. 12:158-166 |
| ISSN: | 2045-4368 2045-435X |
| Popis: | Background and aimThe purpose of this study was to evaluate the health-related quality of life (HRQOL) of patients with multiple sclerosis (MS) globally to provide precise information for policy makers to take necessary steps to improve the quality of life of these patients. This systematic review and meta-analysis is the first global study in the last decade.Materials and methodsData from January 2000 to April 2020 were collected from Scopus, PubMed, Embase, Web of Science and Google Scholar databases on the basis of inclusion and exclusion criteria. Data obtained were analysed by R software, and 54 articles were finally included in the study.ResultsFrom the 2126 articles collected, a total of 54 articles were included in the study. Based on the results of random-effects analysis (DerSimonian and Laird), the mental HRQOL score was 55.18 (95% CI 52.71 to 57.65) and the physical HRQOL score was 48.72 (95% CI 45.93 to 51.52). In this study, age and duration of disease had a significant and direct relationship with mental HRQOL (p≤0.01). Moreover, mental HRQOL was higher in Europe than in other continents, while physical HRQOL was higher in Asia than in other continents. HRQOL was also evaluated on the basis of three valid questionnaires: Short Form 36, Multiple Sclerosis Quality of Life-54 and Multiple Sclerosis International Quality of Life.ConclusionAccording to the results of this study, the total score for HRQOL indicates moderate quality of life. Factors such as depression, age and duration of disease have the greatest impact on HRQOL, whereas factors such as fatigue and the Expanded Disability Status Scale score have less effects on HRQOL, so that patients with MS continue their daily activities as long as they are physically able to, and this happens despite disease progression. |
| Databáze: | OpenAIRE |
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