Tristetraprolin: roles in cancer and senescence
| Autor: | Gerald M. Wilson, Sarah E. Brennan-Laun, Christina R. Ross |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Senescence
Aging RNA Stability Tristetraprolin Gene regulatory network Biology Biochemistry Article Neoplasms Gene expression Animals Humans RNA Processing Post-Transcriptional Molecular Biology Cellular Senescence Genetics AU-rich element Regulation of gene expression Phenotype Cell biology Gene Expression Regulation Neoplastic Cell Transformation Neoplastic Neurology Tumor progression Biotechnology |
| Zdroj: | Ageing research reviews. 11(4) |
| ISSN: | 1872-9649 |
| Popis: | Cancer and senescence are both complex transformative processes that dramatically alter many features of cell physiology and their interactions with surrounding tissues. Developing the wide range of cellular features characteristic of these conditions requires profound alterations in global gene expression patterns, which can be achieved by suppressing, activating, or uncoupling cellular gene regulatory pathways. Many genes associated with the initiation and development of tumors are regulated at the level of mRNA decay, frequently through the activity of AU-rich mRNA-destabilizing elements (AREs) located in their 3′-untranslated regions. As such, cellular factors that recognize and control the decay of ARE-containing mRNAs can influence tumorigenic or senescent phenotypes mediated by products of these transcripts. In this review, we discuss evidence showing how suppressed expression and/or activity of the ARE-binding protein tristetraprolin (TTP) can contribute to these processes. Next, we outline current findings linking TTP suppression to exacerbation of individual tumorigenic phenotypes, and the roles of specific TTP substrate mRNAs in mediating these effects. Finally, we survey potential mechanisms that cells may employ to suppress TTP expression in cancer, and propose potential diagnostic and therapeutic strategies that may exploit the relationship between TTP expression and tumor progression or senescence. |
| Databáze: | OpenAIRE |
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