Transfusion-Transmitted Viruses Study: Experimental Evidence for Two Non-A, Non-B Hepatitis Agents
| Autor: | Wolf Szmuness, R. L. Peters, James W. Mosley, Richard D. Aach, F B Hollinger, Cladd E. Stevens |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Hepatitis
Viral Human Pan troglodytes Cytomegalovirus Antibodies Viral Virus Capsid Antigen Immunity medicine Animals Humans Immunology and Allergy Antigens Viral Hepatitis biology Transfusion Reaction Alanine Transaminase Hepatitis C medicine.disease Virology Vaccination Infectious Diseases Alanine transaminase Immunology biology.protein Antibody |
| Zdroj: | Journal of Infectious Diseases. 142:400-407 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/142.3.400 |
| Popis: | Plasma, serum, and a concentrate of factor VIII, implicated in human cases of non-A, non-B (NANB) hepatitis, were inoculated into four chimpanzees. All four animals demonstrated significant elevations of alanine aminotransferase levels within five weeks. After recovery from these NANB hepatitis episodes, the chimpanzees were cross-challenged with different inocula. A second episode of NANB hepatitis occurred after challenge in three animals. Reproducibility of the results was established by reversing the sequence of inoculation in two of the animals. A known infectious concentrate of factor VIII failed to induce hepatitis in a previously infected chimpanzee although the animal remained susceptible to a third inoculum, an event suggesting that the first inoculum might contain the same NANB hepatitis agent as the concentrate of factor VIII, which was supported by results of a subsequent cross-challenge experiment. Reinfection did not occur in two chimpanzees injected with their initial challenge strain of NANB hepatitis virus, providing evidence that strain-specific immunity had been established. Thus, experimental evidence is provided for the presence of two NANB hepatitis agents, supporting clinical and epidemiologic studies that favor the existence of more than one etiologic agent. Non-A, non-B (NANB) hepatitis remains a diagnosis of exclusion, although evidence for new hepatitis-associated antigens and antibodies is |
| Databáze: | OpenAIRE |
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