The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14–I31) is dispensable for the virus in vitro
| Autor: | Raquel Martinez, Gabriela Bleiber, Amalio Telenti, Solange Peters, Dušan Cmarko, Pascal Meylan |
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| Rok vydání: | 2004 |
| Předmět: |
viruses
medicine.medical_treatment Molecular Sequence Data Human immunodeficiency virus (HIV) Gene Products gag Gene Products pol HIV Infections In Vitro Techniques Biology Virus Replication medicine.disease_cause Central region Virus In vivo Virology medicine Humans Amino Acid Sequence Sequence Deletion Recombination Genetic chemistry.chemical_classification Polymorphism Genetic Protease Virulence In vitro Amino acid Phenotype chemistry HIV-1 Binding domain |
| Zdroj: | Journal of General Virology. 85:921-927 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/vir.0.19576-0 |
| Popis: | The human immunodeficiency virus type 1 p6 region encodes p6Gagand the transframe p6Polprotein. The Gag frame encodes an N-terminal late assembly L domain and a C-terminal Vpr binding domain. In the Pol frame, substitution at a C-terminal motif decreases protease autocleavage. The role of the highly polymorphic central region of p6, comprising amino acids S14–I31 (p6Gag) and R20–D39 (p6Pol), is unclear. Analysis of this central region demonstrated that 35 % of p6Gagappears to be dispensable for virus propagationin vitroand smaller deletion and insertion polymorphisms can be toleratedin vivo. Extensive Pol deletion (ΔR20–D39, 42 % of p6Pol) did not alter protease autocleavage. |
| Databáze: | OpenAIRE |
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