Amyloid deposition in ocular tissues of patients with familial amyloidotic polyneuropathy (FAP)
| Autor: | Masaaki Nakamura, Yukio Ando, Hidenobu Tanihara, Yutaka Tanoue, Hisayasu Terazaki, Hiroaki Okabe, Katsuki Haraoka, Akira Hirata, Ole Sandgren, Eiko Ando, Takahiro Tajiri, Xuguo Sun |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Amyloid Pathology medicine.medical_specialty Conjunctiva genetic structures Eye Internal Medicine Humans Medicine Aged Aged 80 and over Amyloid Neuropathies Familial biology business.industry Amyloidosis Congo Red Middle Aged medicine.disease eye diseases Transthyretin medicine.anatomical_structure Amyloid deposition biology.protein Female sense organs Trabecular meshwork business Polyneuropathy |
| Zdroj: | Amyloid. 9:183-189 |
| ISSN: | 1744-2818 1350-6129 |
| Popis: | It is known that the severity of ocular symptoms does not always correlate with the systemic symptoms in patients with familial amyloidotic polyneuropathy (FAP ATTR V30M). The ocular tissues may have their own TTR metabolic system. The aim of this study is to clarify the distribution of amyloid deposition in the ocular tissues and to investigate the relationship between ocular symptoms and histopathological changes. We analyzed histopathologically 9 autopsied eyes taken from 3 Japanese and 6 Swedish patients with FAP ATTR V30M. Localization of amyloid deposition varied among the different cases, but there were some tendencies in the distribution. The degree of amyloid deposition in the ocular tissues was not always correlated with the duration of the disease. The frequency of amyloid deposition in the conjunctiva, iris, trabecular meshwork and vitreous body were 88.9%, 44.4%, 11.1% and 11.1% respectively in the 9 patients. These frequencies in the histopathological changes correlated with the frequencies in the clinical ocular manifestations as previously reported. |
| Databáze: | OpenAIRE |
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