Influence of Glutathione-S-Transferase A1*B Allele on the Metabolism of the Aromatase Inhibitor, Exemestane, in Human Liver Cytosols and in Patients Treated With Exemestane
| Autor: | Irina Teslenko, Julia Trudeau, Shaman Luo, Christy J.W. Watson, Gang Chen, Cristina I. Truica, Philip Lazarus |
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| Rok vydání: | 2022 |
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| Zdroj: | Journal of Pharmacology and Experimental Therapeutics. 382:327-334 |
| ISSN: | 1521-0103 0022-3565 |
| DOI: | 10.1124/jpet.122.001232 |
| Popis: | Exemestane (EXE) is used to treat postmenopausal women diagnosed with estrogen receptor positive (ER+) breast cancer. A major mode of metabolism of EXE and its active metabolite, 17 |
| Databáze: | OpenAIRE |
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