THE EFFECT OF BILIRUBIN ON THE ENERGY METABOLISM OF BRAIN MITOCHONDRIA
| Autor: | Molly T. Vogt, R. E. Basford |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
medicine.medical_specialty
Bilirubin ATPase Weanling Endogeny Ascorbic Acid Oxidative phosphorylation Mitochondrion Biochemistry Oxidative Phosphorylation Cellular and Molecular Neuroscience chemistry.chemical_compound Oxygen Consumption Glutamates Internal medicine medicine Animals Magnesium Serum Albumin Adenosine Triphosphatases biology Chemistry Albumin Brain Succinates Human serum albumin Mitochondria Rats Endocrinology Animals Newborn biology.protein Dinitrophenols Polarography medicine.drug |
| Zdroj: | Journal of Neurochemistry. 15:1313-1320 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1111/j.1471-4159.1968.tb05909.x |
| Popis: | — Unconjugated bilirubin caused uncoupling of oxidative phosphorylation in brain mitochondria prepared from mature or weanling rats. Human serum albumin in an amount sufficient to bind 100 per cent of the added bilirubin was able to protect the mitochondria from the inhibitory effects of bilirubin. Bilirubin inhibited both the endogenous and DNP-activated ATPase activities but had no effect upon the Mg2+-stimulated ATPase; albumin prevented the inhibition. |
| Databáze: | OpenAIRE |
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