Myofilament dysfunction as an emerging mechanism of volume overload heart failure
| Autor: | Pamela A. Lucchesi, Kristin Wilson |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pressure overload
Heart Failure medicine.medical_specialty Myofilament Physiology Mechanism (biology) business.industry Clinical Biochemistry Volume overload Hemodynamics Dilated cardiomyopathy medicine.disease Myofibrils Physiology (medical) Heart failure Internal medicine medicine Cardiology Animals Humans business Homeostasis Excitation Contraction Coupling |
| Zdroj: | Pflugers Archiv : European journal of physiology. 466(6) |
| ISSN: | 1432-2013 |
| Popis: | Two main hemodynamic overload mechanisms [i.e., volume and pressure overload (VO and PO, respectively] result in heart failure (HF), and these two mechanisms have divergent pathologic alterations and different pathophysiological mechanisms. Extensive evidence from animal models and human studies of PO demonstrate a clear association with alterations in Ca(2+) homeostasis. By contrast, emerging evidence from animal models and patients with regurgitant valve disease and dilated cardiomyopathy point toward a more prominent role of myofilament dysfunction. With respect to VO HF, key features of excitation-contraction coupling defects, myofilament dysfunction, and extracellular matrix composition will be discussed. |
| Databáze: | OpenAIRE |
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