Radiosynthesis of [18F] N-(3-Fluoropropyl)-2-β-Carbomethoxy-3-β-(4-Bromophenyl) Nortropane and the regional brain uptake in non human primate using PET
| Autor: | Thomas Chaly, Ronald M. Baldwin, Vijay Dhawan, Pradeep K. Garg, Matthew J Hellman, David Eidelberg, Sami S. Zoghbi, Yankun Hou, Rushi Zong, Xiao Hui Gu, John L. Neumeyer, Gilles Tamagnan, Mohammed S. Al-Tikriti, Julie K. Staley |
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| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
Metabolic Clearance Rate Nortropanes Metabolite Nerve Tissue Proteins Striatum chemistry.chemical_compound In vivo biology.animal Animals Tissue Distribution Radiology Nuclear Medicine and imaging Dopamine transporter Dopamine Plasma Membrane Transport Proteins Membrane Glycoproteins biology Chemistry Radiosynthesis Radiochemistry Brain Membrane Transport Proteins Imaging agent Biochemistry Isotope Labeling Yield (chemistry) biology.protein Molecular Medicine Female Radiopharmaceuticals Papio Tomography Emission-Computed Baboon |
| Zdroj: | Nuclear Medicine and Biology. 31:125-131 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/s0969-8051(03)00110-0 |
| Popis: | A synthetic procedure for the preparation of [ 18 F]FPCBT, an imaging agent for the dopamine transporter (DAT), has been developed. The radiosynthesis was carried out in a two step procedure. Even though the yield was low, we were able to prepare 20 to 30mCi of the product, which was enough for two or three studies. The radiochemical purity was greater than 96%. The in vivo properties of this radiotracer were evaluated using baboon and it showed highest uptake in the striatum. The studies also revealed that the maximum uptake was reached within 7 to 10 minutes post injection. Plasma metabolite analysis indicated that there is only one metabolite and it is less lipophilic than the parent compound. [ 18 F]FPCBT displayed good brain uptake and its high target to non target ratio indicate that it is a potential candidate for DAT imaging. |
| Databáze: | OpenAIRE |
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