Cocaine administration increases angiotensin I-converting enzyme (ACE) expression and activity in the rat striatum and frontal cortex
| Autor: | Sergio Tufik, Vitor Oliveira, Bruna Visniauskas, Jair R. Chagas, Monica L. Andersen, Fernanda M. Dalio, Juliana C. Perry |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Frontal cortex medicine.medical_treatment Neuroscience(all) Angiotensin I-converting enzyme (ACE) Central nervous system Hippocampus Striatum Peptidyl-Dipeptidase A Angiotensin II (Ang II) Dopamine Uptake Inhibitors Cocaine Internal medicine Renin–angiotensin system Animals Medicine RNA Messenger Saline chemistry.chemical_classification business.industry General Neuroscience Angiotensin II Actins Corpus Striatum Frontal Lobe Rats Endocrinology medicine.anatomical_structure Enzyme chemistry business |
| Zdroj: | Neuroscience Letters. 506(1):84-88 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2011.10.054 |
| Popis: | Some central effects of cocaine administration seem to be related to angiotensin II (Ang II) or its metabolites. Nonetheless, it is still an open question whether or not the levels of angiotensin I-converting enzyme (ACE), the main Ang II generating enzyme, are modified by cocaine administration. To evaluate the effect of acute and subchronic cocaine administration on ACE activity and mRNA expression, male rats were randomly assigned to saline or cocaine group. Acute and subchronic cocaine administration induced a significant increase in ACE activity and mRNA expression in the frontal cortex and striatum but not in the hippocampus. These results suggest that some of the Ang II related effects of cocaine upon the central nervous system can be mediated by changes on the expression and activity of ACE in the striatum and frontal cortex. |
| Databáze: | OpenAIRE |
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