Risk factors associated with the progression of COVID-19 in elderly diabetes patients

Autor:	Yang Wang, Maomao Wang, Ting Li, Pei Zhang, Yifei Wang, Laixing Wang, Jing Zeng, Yanping Gong, Chunlin Li
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Blood Glucose Male BUN blood urea nitrogen Endocrinology Diabetes and Metabolism Glucose levels MODS multiple-organ dysfunction syndrome AST aspartate aminotransferase 0302 clinical medicine Endocrinology ULN upper limit of normal Risk Factors 030212 general & internal medicine COVID-19 coronavirus disease 2019 BNP brain natriuretic peptide Progression LDH lactate dehydrogenase Diabetes cTNI cardiac troponin I General Medicine Middle Aged ICU intensive care unit humanities CT computed tomography Hospitalization CRP C-reactive protein Disease Progression Female medicine.medical_specialty China Coronavirus disease 2019 (COVID-19) APPT activated partial thromboplastin time 030209 endocrinology & metabolism Signs and symptoms Demographic data Article 03 medical and health sciences Internal medicine Diabetes mellitus ALT alanine aminotransferase PT prothrombin time Internal Medicine medicine CHD coronary atherosclerotic heart disease Humans Medical history Risk factor ARDS acute respiratory distress syndrome IQR interquartile range Aged Retrospective Studies BG blood glucose business.industry SARS-CoV-2 MERS Middle East respiratory syndrome COVID-19 Retrospective cohort study T2DM type 2 diabetes mellitus medicine.disease OR odds ratio Pneumonia COPD chronic obstructive pulmonary disease Diabetes Mellitus Type 2 RNA ribonucleic acid business MRI magnetic resonance imaging cTNT cardiac troponin T
Zdroj:	Diabetes Research and Clinical Practice
ISSN:	1872-8227 0168-8227
Popis:	Aim To describe the clinical characteristics and risk factors associated with the progression of COVID-19 in elderly diabetes patients. Methods This was a retrospective cohort study, including elderly COVID-19 patients admitted to Wuhan Huoshenshan Hospital between February 10 and 13, 2020. Demographic data, medical history, signs and symptoms, and laboratory parameters were collected and analysed. Results We included 131 elderly COVID-19 patients (50 patients with diabetes). COVID-19 diabetes patients experienced more severe pneumonia and abnormal organ functions than non-diabetes patients (P 8.0 mmol/L or maximum BG value > 12.0 mmol/L in all elderly patients, and BG value on admission > 5.1 mmol/L or maximum BG value > 5.4 mmol/L in non-diabetes patients. Conclusions Diabetes is an independent important risk factor, and glucose levels associate closely with COVID-19 progression in elderly patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f20332099f5549a61b5258d743f10b0 http://europepmc.org/articles/PMC7833744 Zobrazit plný text záznamu Full Text from ScienceDirect