Free Fatty Acid and Diacylglycerol Accumulation in the Rat Brain During Recurrent Seizures Is Related to Cortical Oxygenation
| Autor: | Nicolas G. Bazan, L. L. Rihn, E B Rodriguez de Turco, Francesco Visioli, N. R. Kreisman |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Partial Pressure Palmitic Acid Palmitic Acids Fatty Acids Nonesterified Biology Biochemistry Diglycerides Electron Transport Complex IV Cellular and Molecular Neuroscience Epilepsy chemistry.chemical_compound Oxygen Consumption Seizures Internal medicine medicine Animals Ictal Diglyceride Rats Wistar Diacylglycerol kinase Cerebral Cortex chemistry.chemical_classification Arachidonic Acid Fatty acid Electroencephalography Oxygenation Carbon Dioxide medicine.disease Rats Oxygen Endocrinology medicine.anatomical_structure chemistry Cerebral blood flow Cerebral cortex Pentylenetetrazole lipids (amino acids peptides and proteins) Oxidation-Reduction Stearic Acids |
| Zdroj: | Journal of Neurochemistry. 61:1835-1842 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1111/j.1471-4159.1993.tb09824.x |
| Popis: | Cerebral blood flow and oxygenation increase during the early seizures of a series, but the increase in cerebral blood flow attenuates during late seizures, sometimes resulting in decreased cortical oxygenation. Cortical free fatty acids (FFA) and diacylglycerols also increase during early seizures and the increase attenuates during late seizures. We analyzed the correlation between lipid accumulation and cortical O2 during periodic pentylenetetrazol-induced seizures. During early seizures, both FFA and diacylglycerols increased in the cerebral cortex, particularly arachidonate (20:4) and stearate (18:0). Changes in lipids were different during late seizures, depending on cortical O2 levels. An increase in cortical O2 during late seizures was associated with lower FFA levels compared with early seizures, and FFA levels recovered to basal levels during interictal periods. A decline in cortical O2 was associated with a further increase in FFA, which remained elevated during interictal periods. Our results indicate that periseizure lipid accumulation is related to cortical oxygenation. |
| Databáze: | OpenAIRE |
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