Measuring the Ocular Morphological Parameters of Guinea Pig Eye with Edge Detection and Curve Fitting

Autor: Zhong-Bao Qiao, Hai-Yun Ye, Wen-Ting Luo, Xingtao Zhou, Tong Qiao, Ying Huang, Na Lu, Ya-Jing Yang, Yue Di
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Models
Anatomic
genetic structures
Article Subject
Computer applications to medicine. Medical informatics
Guinea Pigs
R858-859.7
Diagnostic Techniques
Ophthalmological
Eye
General Biochemistry
Genetics and Molecular Biology
Edge detection
Radius of curvature (optics)
law.invention
Cornea
03 medical and health sciences
0302 clinical medicine
law
medicine
Image Processing
Computer-Assisted
Photography
Animals
Humans
Computer Simulation
030304 developmental biology
Physics
0303 health sciences
General Immunology and Microbiology
Keratometer
Applied Mathematics
Computational Biology
General Medicine
Mathematical Concepts
Circumference
eye diseases
medicine.anatomical_structure
Tilt (optics)
Modeling and Simulation
Models
Animal
030221 ophthalmology & optometry
Curve fitting
sense organs
Eccentricity (mathematics)
Biomedical engineering
Research Article
Zdroj: Computational and Mathematical Methods in Medicine
Computational and Mathematical Methods in Medicine, Vol 2020 (2020)
ISSN: 1748-670X
DOI: 10.1155/2020/6689023
Popis: Aim. To identify the guinea pig eyeball with edge detection and curve fitting and devise a noncontact technology of measuring ocular morphological parameters of small experimental animal. Methods. Thirty-nine eyeballs of guinea pig eyeballs were photographed to obtain the anterior and posterior surface; transverse and sagittal planes after the eyeballs were eviscerated. Next, the eyeball photos were input into digital image analysis software; the corresponding photo pixels-actual length ratio was acquired by a proportional scale. The contour lines of the eyeballs were identified by edge detection technology; conic curve fitting was applied to fit the contour line of the eyeball. The maximum and minimum diameters, the horizontal and vertical diameters, eccentricity, tilt angle, cross-sectional area, equatorial circumference, retrobulbar equatorial maximum length, corneal radius of curvature (CRC) in central region, and the whole cornea were calculated according to the geometric principles. The corneal data of in vitro study were compared with the in vivo results. Results. The contour line of the selected guinea pig eye was identified correctly by edge detection. There were no significant differences between anterior and posterior surfaces of one eyeball in the maximum diameters, eccentricity, cross-sectional area, equatorial circumference, and tilt angle ( P > 0.01 ). There were significant differences of eccentricity and CRC between central region and the whole cornea ( P < 0.01 ). There were no significant differences between keratometer in vivo and cornea in vitro. Conclusion. It was feasible to measure an experimental animal eye in a noncontact way. Edge detection and curve fitting technology could accurately evaluate the ocular morphological parameters.
Databáze: OpenAIRE
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