Effect of caudal epidural steroid or saline injection in chronic lumbar radiculopathy: multicentre, blinded, randomised controlled trial
| Autor: | Bertil Romner, Tore Solberg, Jos W. R. Twisk, Øystein P. Nygaard, Audny Anke, Tor Ingebrigtsen, Trond Iversen, Tom Wilsgaard, Toralf Hasvold |
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| Přispěvatelé: | Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes, Methodology and Applied Biostatistics, EMGO+ - Lifestyle, Overweight and Diabetes |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Lumbar radiculopathy Triamcinolone acetonide medicine.medical_treatment Anti-Inflammatory Agents Injections Epidural Triamcinolone Acetonide law.invention Steroid Randomized controlled trial Double-Blind Method law medicine Back pain Humans Radiculopathy Saline General Environmental Science Pain Measurement business.industry General Engineering SDG 10 - Reduced Inequalities General Medicine Low back pain Surgery Treatment Outcome Anesthesia General Earth and Planetary Sciences Caudal epidural Female medicine.symptom business Low Back Pain medicine.drug |
| Zdroj: | Iversen, T, Solberg, T K, Romner, B, Wilsgaard, T, Twisk, J W, Anke, A, Nygaard, O, Hasvold, T & Ingebrigtsen, T 2011, ' Effect of caudal epidural steroid or saline injection in chronic lumbar radiculopathy: multicentre, blinded, randomised controlled trial ', British Medical Journal, vol. 343, d5278 . https://doi.org/10.1136/bmj.d5278 British Medical Journal, 343:d5278 BMJ. British Medical Journal British Medical Journal, 343:d5278. BMJ Publishing Group |
| ISSN: | 0959-535X |
| DOI: | 10.1136/bmj.d5278 |
| Popis: | Objective: To assess the efficacy of caudal epidural steroid or saline injection in chronic lumbar radiculopathy in the short (6 weeks), intermediate (12 weeks), and long term (52 weeks). Design: Multicentre, blinded, randomised controlled trial. Setting: Outpatient multidisciplinary back clinics of five Norwegian hospitals. Participants: Between October 2005 and February 2009, 461 patients assessed for inclusion (presenting with lumbar radiculopathy >12 weeks). 328 patients excluded for cauda equina syndrome, severe paresis, severe pain, previous spinal injection or surgery, deformity, pregnancy, ongoing breast feeding, warfarin therapy, ongoing treatment with non-steroidal anti-inflammatory drugs, body mass index >30, poorly controlled psychiatric conditions with possible secondary gain, and severe comorbidity. Interventions: Subcutaneous sham injections of 2 mL 0.9% saline, caudal epidural injections of 30 mL 0.9% saline, and caudal epidural injections of 40 mg triamcinolone acetonide in 29 mL 0.9% saline. Participants received two injections with a two week interval. Main outcome measures: Primary: Oswestry disability index scores. Secondary: European quality of life measure, visual analogue scale scores for low back pain and for leg pain. Results: Power calculations required the inclusion of 41 patients per group. We did not allocate 17 of 133 eligible patients because their symptoms improved before randomisation. All groups improved after the interventions, but we found no statistical or clinical differences between the groups over time. For the sham group (n=40), estimated change in the Oswestry disability index from the adjusted baseline value was -4.7 (95% confidence intervals -0.6 to -8.8) at 6 weeks, -11.4 (-6.3 to -14.5) at 12 weeks, and -14.3 (-10.0 to -18.7) at 52 weeks. For the epidural saline intervention group (n=39) compared with the sham group, differences in primary outcome were -0.5 (-6.3 to 5.4) at 6 weeks, 1.4 (-4.5 to 7.2) at 12 weeks, and -1.9 (-8.0 to 4.3) at 52 weeks; for the epidural steroid group (n=37), corresponding differences were -2.9 (-8.7 to 3.0), 4.0 (-1.9 to 9.9), and 1.9 (-4.2 to 8.0). Analysis adjusted for duration of leg pain, back pain, and sick leave did not change this trend. Conclusions: Caudal epidural steroid or saline injections are not recommended for chronic lumbar radiculopathy. Trial registration: Current Controlled Trials ISRCTN No 12574253. |
| Databáze: | OpenAIRE |
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