Drinking Behavior in Water Deprived Rats after Angiotensin Receptor Blockade
| Autor: | J.M. Kapsha, Patricia A. Klase, Lanny C. Keil, Walter B. Severs |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Angiotensin receptor medicine.medical_specialty Vasopressin Vasopressins medicine.drug_class Drinking Behavior Receptors Cell Surface Plasma renin activity chemistry.chemical_compound Internal medicine Renin Renin–angiotensin system medicine Animals Receptor Injections Intraventricular Pharmacology Receptors Angiotensin Water Deprivation Angiotensin II Sodium General Medicine Receptor antagonist Rats Endocrinology Hematocrit chemistry Injections Intravenous Saralasin |
| Zdroj: | Pharmacology. 15:254-258 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000136696 |
| Popis: | Angiotensin II is a peptide normally present in the bloodstream and central nervous system. Exogenous angiotensin induces drinking which is inhibited by saralasin, a specific receptor antagonist. Administration of saralasin does not reduce endogenously stimulated drinking. Angiotensin is dipsogenic after intravenous or intracerebroventricular infusion, raising the possibility of multiple access routes to the brain. Water deprived rats were given saralasin by both routes simultaneously to block the access of endogenous angiotensin to receptors reached from blood and ventricular cerebrospinal fluid (CSF). Water deprivation increased plasma (Na+), hematocrit, vasopressin content and renin activity but saralasin treatment did not reduce water intake after 30 or 60 min. Therefore, blood or CSF-borne angiotensin does not appear to be an absolute requirement for water deprivation drinking behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|