Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids
| Autor: | Sarah L. O’Beirne, Yael Strulovici-Barel, Robert J. Kaner, Ronald G. Crystal, Jacqueline Salit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Time Factors ACE2 Respiratory Mucosa medicine.disease_cause Young Adult 03 medical and health sciences Diseases of the respiratory system 0302 clinical medicine Adrenal Cortex Hormones Administration Inhalation medicine Maintenance inhaled corticosteroids Humans Young adult Coronavirus Asthma RC705-779 business.industry SARS-CoV-2 Research Case-control study COVID-19 Middle Aged Virus Internalization Eosinophil Large airway epithelium medicine.disease Up-Regulation 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Case-Control Studies Host-Pathogen Interactions Angiotensin-converting enzyme 2 Immunology Receptors Virus Respiratory epithelium Female Angiotensin-Converting Enzyme 2 Gene expression business Airway hormones hormone substitutes and hormone antagonists |
| Zdroj: | Respiratory Research, Vol 22, Iss 1, Pp 1-8 (2021) Respiratory Research |
| Popis: | Background The first step in SARS-CoV-2 infection is binding of the virus to angiotensin converting enzyme 2 (ACE2) on the airway epithelium. Asthma affects over 300 million people world-wide, many of whom may encounter SARS-CoV-2. Epidemiologic data suggests that asthmatics who get infected may be at increased risk of more severe disease. Our objective was to assess whether maintenance inhaled corticosteroids (ICS), a major treatment for asthma, is associated with airway ACE2 expression in asthmatics. Methods Large airway epithelium (LAE) of asthmatics treated with maintenance ICS (ICS+), asthmatics not treated with ICS (ICS−), and healthy controls (controls) was analyzed for expression of ACE2 and other coronavirus infection-related genes using microarrays. Results As a group, there was no difference in LAE ACE2 expression in all asthmatics vs controls. In contrast, subgroup analysis demonstrated that LAE ACE2 expression was higher in asthmatics ICS+ compared to ICS‾ and ACE2 expression was higher in male ICS+ compared to female ICS+ and ICS‾ of either sex. ACE2 expression did not correlate with serum IgE, absolute eosinophil level, or change in FEV1 in response to bronchodilators in either ICS− or ICS+. Conclusion Airway ACE2 expression is increased in asthmatics on long-term treatment with ICS, an observation that should be taken into consideration when assessing the use of inhaled corticosteroids during the pandemic. |
| Databáze: | OpenAIRE |
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