Long-term oncologic outcomes of liver resection for hepatocellular carcinoma in adolescents and young adults: A multicenter study from a hepatitis B virus-endemic area
| Autor: | Xin-Ping Fan, Yong-Kang Diao, Dong-Sheng Huang, Lei Liang, Chao Li, Han Wu, Wan Yee Lau, Zhi-Yu Chen, Wei-Min Gu, Ya-Hao Zhou, Tian Yang, Cheng-Wu Zhang, Jian-Yu Wang, Hong Wang, Ting-Hao Chen, Feng Shen, Jun-Wei Liu, Ming-Da Wang, Ying-Jian Liang, Jie Li |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male China medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Adolescent medicine.medical_treatment medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Young adult Pathological Hepatitis B virus business.industry Incidence (epidemiology) Liver Neoplasms General Medicine Perioperative Hepatitis B medicine.disease humanities Survival Rate 030220 oncology & carcinogenesis Hepatocellular carcinoma Female 030211 gastroenterology & hepatology Surgery Neoplasm Recurrence Local Hepatectomy business |
| Zdroj: | The American Journal of Surgery. 222:751-758 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2021.03.009 |
| Popis: | Background Hepatocellular carcinoma (HCC) is common among adolescents and young adults (AYAs) in areas with endemic hepatitis B virus infection. We sought to characterize clinical features and long-term outcomes among AYAs versus older adults (OAs) who underwent HCC resection. Methods From a Chinese multicenter database, patients were categorized as AYA (aged 13–39 years) versus OA (aged ≥40 years). Patient clinical features, perioperative outcomes, overall survival (OS) and time-to-recurrence (TTR) were compared. Multivariable Cox-regression analyses were performed to identify the impact of age on OS and TTR. Results Among 1952 patients, 354(22.2%) were AYAs. AYAs were less likely to have cirrhosis yet were likely to have advanced tumor pathological characteristics than OAs. Postoperative morbidity and mortality were comparable. Compared with OAs, AYAs had a comparable OS but a decreased TTR. Multivariable analyses identified that young age ( Conclusions Compared with OAs, AYAs had a higher incidence of recurrence following liver resection among patients with HCC, suggesting that enhanced surveillance for postoperative recurrence may be required among AYAs. |
| Databáze: | OpenAIRE |
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