A-kinase anchoring proteins: molecular regulators of the cardiac stress response
| Autor: | Irene Pérez López, Darko Maric, Sabrina Cavin, Cosmo D. del Vescovo, Dario Diviani |
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| Rok vydání: | 2012 |
| Předmět: |
A Kinase Anchor Proteins
Cardiomegaly Cardiomyocyte Biology Muscle hypertrophy Fight-or-flight response Protein kinase A Fibrosis Stress Physiological medicine Cyclic AMP Humans Myocytes Cardiac Hypoxia Molecular Biology Cardiac remodeling Myocardium Cell Biology A kinase anchoring protein (AKAP) medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit Adaptation Physiological Signaling Cell biology Oxygen Gene Expression Regulation Heart failure Cardiac hypertrophy A kinase Signal transduction Protein Binding Signal Transduction |
| Zdroj: | Biochimica et biophysica acta. 1833(4) |
| ISSN: | 0006-3002 |
| Popis: | In response to stress or injury the heart undergoes a pathological remodeling process, associated with hypertrophy, cardiomyocyte death and fibrosis, that ultimately causes cardiac dysfunction and heart failure. It has become increasingly clear that signaling events associated with these pathological cardiac remodeling events are regulated by scaffolding and anchoring proteins, which allow coordination of pathological signals in space and time. A-kinase anchoring proteins (AKAPs) constitute a family of functionally related proteins that organize multiprotein signaling complexes that tether the cAMP-dependent protein kinase (PKA) as well as other signaling enzymes to ensure integration and processing of multiple signaling pathways. This review will discuss the role of AKAPs in the cardiac response to stress. Particular emphasis will be given to the adaptative process associated with cardiac hypoxia as well as the remodeling events linked to cardiac hypertrophy and heart failure. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Cardiac Pathways of Differentiation, Metabolism and Contraction. |
| Databáze: | OpenAIRE |
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