Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia
| Autor: | Lucia E. Duinhouwer, Leo F. Verdonck, Wil A. Allebes, E. Meijer, Eefke Petersen, Anton Schattenberg, M. Groenendijk-Sijnke, Roelof Willemze, Machteld Oudshoorn, T. Lodewyck, Bob Löwenberg, Jan J. Cornelissen, B. van der Holt, P.A. von dem Borne, Eric Spierings |
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| Přispěvatelé: | Hematology, Erasmus MC other |
| Rok vydání: | 2011 |
| Předmět: |
Oncology
Adult Male Risk Cancer Research medicine.medical_specialty medicine.medical_treatment T-Lymphocytes Hematopoietic stem cell transplantation Disease Histocompatibility Testing Translational research [ONCOL 3] Recurrence Internal medicine medicine Humans acute leukemia Stage (cooking) Alleles unrelated donor transplantation Bone Marrow Transplantation Acute leukemia Framingham Risk Score Leukemia business.industry Hematology Surgery Transplantation allele-matching Myelodysplastic Syndromes Acute Disease Female Risk assessment business |
| Zdroj: | Leukemia, 25, 10, pp. 1548-54 Leukemia, 25(10), 1548. Nature Publishing Group Leukemia, 25, 1548-54 Leukemia, 25(10), 1548-1554. Nature Publishing Group Leukemia, 25(10), 1548-1554 |
| ISSN: | 0887-6924 |
| Popis: | Many parameters predict for outcome after unrelated donor (URD) allogeneic hematopoietic stem cell transplantation (alloSCT). High-resolution HLA-matching significantly impacts outcome and also the European Group of Blood and Marrow Transplantation (EBMT) risk score, based on patient age, disease stage, donor type, time from diagnosis to SCT and gender combination, may predict for non-relapse mortality and overall survival (OS). We evaluated the individual and combined effects of allele-matching and the EBMT risk score in 327 patients with poor-risk acute leukemia or myelodysplasia, who received a T-cell depleted URD alloSCT. Matching for HLA-A, -B, -C and -DRB1 alleles (8/8 match) was associated with a 5-year OS of 40% compared with 30% for mismatched ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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