Decreased expression of C10orf10 and its prognostic significance in human breast cancer
| Autor: | Gang Meng, Wen-wei Zuo, Yan Dong, Jianjun Li, Junjiang Deng, Cheng-ping Xu, Chong Li |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology Microarray Genetic Causes of Cancer Cancer Treatment lcsh:Medicine Gene Expression Breast Neoplasms Kaplan-Meier Estimate Breast cancer Internal medicine Gene expression medicine Medicine and Health Sciences Humans lcsh:Science Molecular Biology Techniques Molecular Biology Survival analysis Proportional Hazards Models Multidisciplinary business.industry Proportional hazards model Cancer Risk Factors lcsh:R Case-control study Intracellular Signaling Peptides and Proteins Cancer Proteins Biology and Life Sciences Gene Therapy medicine.disease Prognosis Case-Control Studies Lymphatic Metastasis lcsh:Q Female DNA microarray business Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 6, p e99730 (2014) |
| ISSN: | 1932-6203 |
| Popis: | Breast cancer is a common malignant tumor, which severely threatens the health of women with an increasing incidence in many countries. Here, we identified C10orf10 as a novel differentially expression gene using expression microarray screening. The expression analysis indicated that C10orf10 was frequently decreased in human breast cancers compared to noncancerous breast tissues (81/95, P = 0.0063). Kaplan-Meier analysis indicated that patients with low C10orf10 expression showed a poorer prognosis both in mRNA (n = 1115, P = 0.0013) and protein (n = 100, P = 0.003) levels. Univariate and multivariate analysis showed that the C10orf10 expression was an independent prognostic factor for overall survival of breast cancer patients. Further analysis revealed that low expression of C10orf10 was an unfavorable factor for the prognosis of the patients who were luminal A, luminal B, Her2+ subtypes, at histological grade 2, lymph node negative and ER positive. Our data provided the first evidence that C10orf10 expression was frequently decreased in breast cancer tissues, and low expression of C10orf10 may be an important prognostic factor for poorer survival time of breast cancer patients. |
| Databáze: | OpenAIRE |
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