Antithyroglobulin antibody as a marker of successful ablation therapy in differentiated thyroid cancer
| Autor: | Ayu Rosemeilia Dewi, Johan S. Masjhur, Achmad Hussein Sundawa Kartamihadja, Budi Darmawan, Basuki Hidayat |
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| Rok vydání: | 2017 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty lcsh:R895-920 medicine.medical_treatment 030209 endocrinology & metabolism Gastroenterology 030218 nuclear medicine & medical imaging Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine thyroid cancer medicine thyroglobulin (Tg) Thyroid cancer business.industry Thyroidectomy Retrospective cohort study Odds ratio medicine.disease Ablation Confidence interval Surgery Antithyroglobulin antibody (ATA) Original Article Histopathology I-131 ablation business |
| Zdroj: | World Journal of Nuclear Medicine World Journal of Nuclear Medicine, Vol 16, Iss 1, Pp 15-20 (2017) |
| ISSN: | 1607-3312 1450-1147 |
| DOI: | 10.4103/1450-1147.174714 |
| Popis: | The aim of this study was to determine the role of antithyroglobulin antibody (ATA) serum as a marker of successful I-131 ablation therapy in differentiated thyroid cancer (DTC) patients with low serum thyroglobulin (Tg). A retrospective study was conducted on 60 patients (10 males and 50 females). All patients underwent posttotal thyroidectomy and received 2.96 to 3 GBq I-131 ablation. Subjects were divided into two groups with succesful and unsuccessful I-131 ablation therapies. The data of age, gender, histopathologic type, tumor size, and metastasis were collected. Preablation serum Tg and ATA level (Tg1 and ATA1) 6-12 months after ablation (Tg2 and ATA2) were measured. The success of ablation therapy was evaluated by diagnostic whole body scan (DxWBS) 6-12 months after ablation. There were no significant differences in age, gender, type of histopathology, tumor size, and nodal metastasis between the two groups. ATA2 ≤30 kIU/L were found in 23 (62.2%) subjects with successful ablation therapy, and ATA2 >30 kIU/L in 16 (69.6%) subjects belonged to the unsuccessful group (P = 0.017). Changes between ATA1 and ATA2 levels did not differ significantly in both the groups (P = 0.062). Tg1 |
| Databáze: | OpenAIRE |
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