Chronic Clenbuterol Administration Alters Myosin Heavy Chain Composition in Standardbred Mares
| Autor: | Kenneth H. McKeever, Matthew D. Beekley, J M. Ideus, C. F. Kearns, J B. Brown |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Physical Therapy Sports Therapy and Rehabilitation Bronchodilator Internal medicine Myosin medicine Animals Clenbuterol Orthopedics and Sports Medicine Horses Muscle Skeletal Gluteus medius muscle Myosin Heavy Chains General Veterinary Fiber type Chemistry Horse Adrenergic beta-Agonists Surgery Endocrinology Female Animal Science and Zoology Composition (visual arts) medicine.drug |
| Zdroj: | The Veterinary Journal. 165:234-239 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/s1090-0233(02)00178-8 |
| Popis: | The purpose of this study was to examine changes in myosin heavy chain (MHC) composition due to chronic clenbuterol administration with or without exercise in mares. Unfit Standardbred mares (aged 10+/-3 years) were divided into four groups: clenbuterol (2.4 micro/kg BW twice daily) plus exercise (3 days/week for 20 min at 50% VO(2max); CLENEX; n=6), clenbuterol only (CLEN; n=6), exercise only (EX; n=5), and control (CON; n=6). Muscle biopsies were obtained from gluteus medius muscle before and after the eight-week training/administration period. MHC composition was determined via SDS gel electrophoresis and quantified using a scanning and densometric system. CLENEX and CLEN exhibited significant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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