Measuring the repertoire of age-related behavioral changes in Drosophila melanogaster
| Autor: | Katherine E. Overman, Daniel M. Choi, Kawai Leung, Joshua W. Shaevitz, Gordon J. Berman |
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| Rok vydání: | 2021 |
| Předmět: |
Aging
Longevity FOS: Physical sciences Quantitative Biology - Quantitative Methods Cellular and Molecular Neuroscience 03 medical and health sciences 0302 clinical medicine Age related Genetics Melanogaster Animals Physics - Biological Physics Molecular Biology Quantitative Methods (q-bio.QM) Ecology Evolution Behavior and Systematics Organism 030304 developmental biology 0303 health sciences Behavior Animal Ecology biology Repertoire biology.organism_classification Sexual dimorphism Stereotypy (non-human) Drosophila melanogaster Computational Theory and Mathematics Biological Physics (physics.bio-ph) Evolutionary biology FOS: Biological sciences Modeling and Simulation Drosophila 030217 neurology & neurosurgery |
| Popis: | Aging affects almost all aspects of an organism – its morphology, its physiology, its behavior. Isolating which biological mechanisms are regulating these changes, however, has proven difficult, potentially due to our inability to characterize the full repertoire of an animal’s behavior across the lifespan. Using data from fruit flies (D. melanogaster) we measure the full repertoire of behaviors as a function of age. We observe a sexually dimorphic pattern of changes in the behavioral repertoire during aging. Although the stereotypy of the behaviors and the complexity of the repertoire overall remains relatively unchanged, we find evidence that the observed alterations in behavior can be explained by changing the fly’s overall energy budget, suggesting potential connections between metabolism, aging, and behavior. |
| Databáze: | OpenAIRE |
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