Association between Endothelial Nitric Oxide Synthase Gene Polymorphism (Glu298Asp) and Coronary No-Reflow Phenomenon in Acute Myocardial Infarction
| Autor: | Ismail Biyik, Burce Yalcin, Aydin Rodi Tosu, Ahmet Yalcin, Mehmet Erturk, Veysel Sabri Hancer, Faruk Akturk, Ali Birant |
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| Přispěvatelé: | Uşak Üniversitesi |
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty coronary no-reflow phenomenon lcsh:Medicine 030209 endocrinology & metabolism myocardial infarction nitric oxide synthase Glu298Asp gene variant 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine cardiovascular diseases Myocardial infarction Endothelial nitric oxide synthase business.industry lcsh:R medicine.disease Infectious Diseases 030220 oncology & carcinogenesis No reflow phenomenon cardiovascular system Cardiology Gene polymorphism business |
| Zdroj: | Postępy Higieny i Medycyny Doświadczalnej, Vol 73, Pp 529-535 (2019) |
| ISSN: | 1732-2693 0032-5449 |
| DOI: | 10.5604/01.3001.0013.5253 |
| Popis: | WOS: 000490553700005 Aim: No-reflow phenomenon is an important complication of primary percutaneous coronary intervention. Several variants in the endothelial nitric oxide synthase gene, which reduce endothelial nitric oxide synthase activity, are a risk factor for coronary heart disease. However, its role in no-reflow phenomenon has not yet been revealed. This study aimed to investigate whether there is a relationship between endothelial nitric oxide synthase Glu298Asp gene variant and the development of coronary no-reflow phenomenon in patients with ST elevation myocardial infarction. Material/Methods: The study was conducted among 116 patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction. Group 1 included 52 ST elevation myocardial infarction patients undergoing no-reflow phenomenon as a study group. Group 2 comprised 64 ST elevation myocardial infarction patients without no-reflow phenomenon as a control group. Endothelial nitric oxide synthase was tested using polymerase chain reaction-restriction fragment length variant. Results: The prevalence of TT genotype of endothelial nitric oxide synthase Glu298Asp gene variant was found to be significantly higher in patients developing coronary no-reflow when compared to those without no-reflow (p = 0.016; 11.54% vs. 1.56%) (OR = 10.85, 95% CI = 1.22-96.39). However, a similar association for the heterozygous GT genotype of endothelial nitric oxide synthase Glu298Asp gene variant was not observed between the two groups. Conclusions: The results of this preliminary study indicate that there is an association between Glu298Asp variant in endothelial nitric oxide synthase gene and the development of no-reflow phenomenon in ST elevation myocardial infarction. The presence of homozygous TT allele may contribute to tendency to the development of no-reflow phenomenon. |
| Databáze: | OpenAIRE |
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