Hepatitis C infection in an Italian population not selected for risk factors
| Autor: | M. Posca, S. Armitano, D. Gola, P. G. Vegezzi, G. Perricone, K. Komla‐Ebri, L. Brambilla, G. Maggi, M. Cairo, G. Galvani, E. Marmondi, C. Vergani, Giuseppe De Leo, M. Brenna |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype Population Immunoblotting Viremia Hepacivirus Risk Factors Internal medicine Epidemiology medicine Prevalence Humans Risk factor education Aged education.field_of_study Hepatology business.industry Alanine Transaminase Hepatitis C Hepatitis C Antibodies Middle Aged medicine.disease Italy Immunology RNA Viral Female Viral disease business Body mass index |
| Zdroj: | Liver. 19(5) |
| ISSN: | 0106-9543 |
| Popis: | Aims/Background: This study estimated the prevalence of HCV infection and relationship with viremia in a general population. The inhabitants of Albavilla town were personally invited to participate. Methods: Out of 3997 inhabitants falling within the age range 18–85 years, 2403 (participation rate 60.1%) were examined for transaminases, HCVAb, HCVRNA, genotype and immunoblot assay. The following information was collected: sex, age, blood transfusions, surgery, use of glass syringes, drug addiction, alcohol consumption, tattoos and body mass index. Results: 115 (4.8%) were HCVAb+, the prevalence being 1.2% under 40 years. Transfusion in the past was the only risk factor for HCV infection. Among the HCVAb+ subjects, 71 (61.7%) were HCVRNA+. 40.8% of the HCVAb+/HCVRNA+ group had normal ALT, compared with 68% of those with HCVAb+/HCVRNA-. The HCV genotypes in the 71 HCVRNA+ subjects were: 2a/2c in 58 (81.7%), 40% of them with normal ALT;1b in 11 (15.5%), none with normal ALT; genotype 3 in two (2.8%). Conclusion: The prevalence of HCVAb in this general population was 4.8%. About 3% were HCVRNA positive and of these genotype 2a/ 2c was present in 81.6%. |
| Databáze: | OpenAIRE |
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