The multiple function of long noncoding RNAs in osteosarcoma progression, drug resistance and prognosis
| Autor: | Hongyuan Xing, Yingchao Gong, Ning Zhang, Ying Yin, Sheng-Jie Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Signaling pathways Carcinogenesis Resistance Bone Neoplasms RM1-950 Drug resistance Bioinformatics medicine.disease_cause Phosphatidylinositol 3-Kinases 03 medical and health sciences 0302 clinical medicine medicine Humans Wnt Signaling Pathway Pathological Pharmacology Osteosarcoma Receptors Notch business.industry General Medicine Therapeutic resistance Prognosis medicine.disease Research findings Long non-coding RNA 030104 developmental biology 030220 oncology & carcinogenesis Multiple function Disease Progression RNA Long Noncoding Therapeutics. Pharmacology business Proto-Oncogene Proteins c-akt Long noncoding RNA |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 127, Iss, Pp 110141-(2020) |
| ISSN: | 0753-3322 |
| Popis: | Osteosarcoma is a bone tumor prevalent in children and young adults. LncRNAs are a family of non-protein-coding transcripts longer than 200 nucleotides. The tumor-related pathological functions of lncRNAs include proliferation, migration, and chemotherapy resistance, all of which have been widely acknowledged in research on osteosarcoma. In addition, compelling evidence suggests that lncRNAs could serve as diagnostic indicators, prognostic biomarkers, and targets for disease treatment. In this review, we systematically summarize how lncRNAs regulate tumorigenesis, invasion and therapeutic resistance. By deepening our knowledge of the relationship between lncRNAs and osteosarcoma, we hope to translate research findings into clinical applications as soon as possible. |
| Databáze: | OpenAIRE |
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