Insulin-like growth factor I: a modulator of erythropoiesis in uraemic patients?
| Autor: | Armin Kurtz, Kai-Uwe Eckardt, A. Bonnardeaux, Tilman B. Drüeke, Pablo Ureña |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia medicine.medical_treatment 610 Medizin Hematocrit Insulin-like growth factor Uremia/physiopathology Hyperparathyroidism Secondary/etiology Internal medicine hemic and lymphatic diseases medicine Humans 570 Biowissenschaften Biologie Transplantation Kidney Hyperparathyroidism Insulin-Like Growth Factor I/physiology ddc:610 medicine.diagnostic_test business.industry Insulin Erythropoiesis/physiology Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Nephrology Erythropoietin Erythropoiesis Female ddc:570 business Anemia/etiology medicine.drug |
| Popis: | Anaemia is a feature almost invariably complicating chronic renal failure. Its pathophysiology is multifactorial but the most important cause is erythropoietin (Epo) deficiency. However, either no relation or even a weakly positive relation generally exists between serum immunoreactive (i) Epo and haematocrit values in uraemic anaemia, whereas in anaemias of non-renal origin the correlation is most often strongly negative. Recent evidence indicates that growth hormone also stimulates erythropoiesis. Moreover, late erythroid progenitor cells (CFU-E) require insulin and/or insulin-like growth factor I (IGF-I) for development in vitro. IGF-I has been shown to have a synergistic action with Epo. We have measured serum iEpo and IGF-I levels in 17 haemodialysis patients with severe hyperparathyroidism (mean +/- SEM serum iPTH, 988 +/- 88 pg/ml). Mean age and duration of dialysis treatment were 46.1 +/- 3.4 and 8.8 +/- 1.0 years respectively. Mean haematocrit and haemoglobin values wer 28.1 +/- 1.7% and 9.39 +/- 0.54 g/dl respectively. Mean serum iEpo and IGF-I levels were 20.3 +/- 4.7 mU/ml and 320 +/- 20 ng/ml respectively (normal values for serum iEpo and IGF-I, 17.9 +/- 6 mU/ml and 91 +/- 23 ng/ml respectively). We found that serum IGF-I concentrations were well correlated with haematocrit values (r = 0.68, n = 15, P less than 0.004) whereas serum iEpo values were not (r = 0.41, n = 12, P = 0.18). IGF-I could therefore be an important factor regulating erythropoiesis in uraemic patients, at least when associated with severe hyperparathyroidism. |
| Databáze: | OpenAIRE |
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