Ambiguity about Splicing Factor 3b Subunit 3 (SF3B3) and Sin3A Associated Protein 130 (SAP130)
| Autor: | Metselaar, Paula I, Hos, Celine, Welting, Olaf, Bosch, Jos A, Kraneveld, Aletta D, de Jonge, Wouter J, Te Velde, Anje A, Afd Pharmacology, Pharmacology |
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| Přispěvatelé: | Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, Medical Psychology, APH - Mental Health, Gastroenterology and Hepatology, AII - Inflammatory diseases, Klinische Psychologie (Psychologie, FMG), Afd Pharmacology, Pharmacology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
spliceosome-associated protein 130
Protein subunit Gene Expression Biology Splicing factor Ileum Terminology as Topic OMIM : Online Mendelian Inheritance in Man SIN3A Humans Splicing factor 3b subunit 3 Intestinal Mucosa splicing factor 3b subunit 3 lcsh:QH301-705.5 Sin3A associated protein 130 Genetics Inflammation Medicine(all) Communication SAP130 Antibodies Monoclonal SF3B3 General Medicine Ligand (biochemistry) Immunohistochemistry Spliceosome-associated protein 130 Histone Liver lcsh:Biology (General) Histone deacetylase complex biology.protein RNA Splicing Factors Corepressor |
| Zdroj: | Cells, 10(3):590, 1-8. MDPI Multidisciplinary Digital Publishing Institute Cells, 10(3):590. MDPI Cells, Vol 10, Iss 590, p 590 (2021) Cells, 10(3), 1. Multidisciplinary Digital Publishing Institute (MDPI) Cells |
| ISSN: | 2073-4409 |
| Popis: | In 2020, three articles were published on a protein that can activate the immune system by binding to macrophage-inducible C-type lectin receptor (Mincle). In the articles, the protein was referred to as ‘SAP130, a subunit of the histone deacetylase complex.’ However, the Mincle ligand the authors aimed to investigate is splicing factor 3b subunit 3 (SF3B3). This splicing factor is unrelated to SAP130 (Sin3A associated protein 130, a subunit of the histone deacetylase-dependent Sin3A corepressor complex). The conclusions in the three articles were formulated for SF3B3, while the researchers used qPCR primers and antibodies against SAP130. We retraced the origins of the ambiguity about the two proteins and found that Online Mendelian Inheritance in Man (OMIM) added a Nature publication on SF3B3 as a reference for Sin3A associated protein 130 in 2016. Subsequently, companies such as Abcam referred to OMIM and the Nature article in their products for both SF3B3 and SAP130. In turn, the mistake by OMIM followed in the persistent and confusing use of ‘SAP130′ (spliceosome-associated protein 130) as an alternative symbol for SF3B3. With this report, we aim to eliminate the persistent confusion and separate the literature regarding the two proteins. |
| Databáze: | OpenAIRE |
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