Genetic Polymorphisms of Killer Cell Immunoglobulin-Like Receptors Are Associated with Susceptibility to Psoriasis Vulgaris
| Autor: | Yu Suzuki, Yoshiaki Yoshikawa, Yumie Ogasawara, Masahiko Muto, Takehiko Sasazuki, Yoshiaki Hamamoto, Kimi Ishikawa |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Genotype
T lymphocytes Dermatology Biology Biochemistry Natural killer cell Psoriatic arthritis Japan Receptors KIR Psoriasis medicine Humans Genetic Predisposition to Disease Receptors Immunologic Receptor Molecular Biology immunologic receptors natural killer cells Polymorphism Genetic Haplotype Immunologic receptor disease susceptibility Cell Biology medicine.disease major histocompatibility complex Killer Cells Natural medicine.anatomical_structure Receptors KIR2DL2 Receptors KIR2DL1 Immunology biology.protein Antibody |
| Zdroj: | Journal of Investigative Dermatology. 122:1133-1136 |
| ISSN: | 0022-202X |
| DOI: | 10.1111/j.0022-202x.2004.22517.x |
| Popis: | To elucidate the association between killer cell immunoglobulin-like receptors (KIRs) and psoriasis vulgaris (PV), we typed 14 KIR genes in 96 Japanese cases and 50 healthy controls using PCR with sequence-specific primers (PCR-SSP). Here we report an interesting association between certain KIRs and Japanese cases with PV. The frequencies of KIR2DS1 and KIR2DL5 were significantly increased in PV cases compared with controls (KIR2DS1, 43 of 96 (45%) in cases vs 14 of 50 (28%) in controls; KIR2DL5, 46 of 96 (48%) in cases vs 15 of 50 (30%) in controls, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|