Molecular Oncology in Management of Colorectal Cancer
| Autor: | Bhawna Sirohi, Sanjeev Vasudev Katti, Govind Nandakumar, Ramraj Nagendra Gupta Vemala, Divya Manikandan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer business.industry Disease progression Microsatellite instability medicine.disease Molecular oncology 03 medical and health sciences Regimen 0302 clinical medicine Surgical oncology 030220 oncology & carcinogenesis Internal medicine medicine Effective treatment 030211 gastroenterology & hepatology Surgery Molecular Profile Original Article business |
| Zdroj: | Indian J Surg Oncol |
| ISSN: | 0975-7651 |
| Popis: | Colorectal cancers are the third most common cancers in the world. Management of both primary and metastatic colorectal cancers has evolved over the last couple of decades. Extensive research in molecular oncology has helped us understand and identify these complex intricacies in colorectal cancer biology and disease progression. These advances coupled with improved knowledge on various mutations have helped develop targeted chemotherapeutics and has allowed planning an effective treatment regimen in this era of immunotherapy with precision. The diverse chemotherapeutic and biological agents at our disposal can make decision making a very complex process. Molecular profile, including CIN, RAS, BRAF mutations, microsatellite instability, ctDNA, and consensus molecular subtypes, are some of the important factors which are to be considered while planning an individualized treatment regimen. This article summarizes the current status of molecular oncology in the management of colorectal cancer and should serve as a practical guide for the clinical team. |
| Databáze: | OpenAIRE |
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