Defining new clinically derived criteria for high disease activity in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study
| Autor: | Minna-Maija Grönlund, Paula Keskitalo, Eliisa Löyttyniemi, Paula Vähäsalo, Pirjo Tynjälä, Maria Backström, Johanna Kärki, Heini Pohjankoski, Kristiina Aalto, Helena Lehto, Sirja Sard, Heikki Ylijoki, Maiju Hietanen, Anne Putto-Laurila, Silke Witter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
030203 arthritis & rheumatology
0301 basic medicine musculoskeletal diseases medicine.medical_specialty Oligoarthritis Receiver operating characteristic Concise Report business.industry Arthritis Disease Outcome assessment medicine.disease Disease activity 03 medical and health sciences Juvenile Arthritis Disease Activity Score 030104 developmental biology 0302 clinical medicine Rheumatology Internal medicine juvenile idiopathic arthritis Medicine Polyarthritis business disease activity outcome assessment |
| Zdroj: | Rheumatology Advances in Practice |
| ISSN: | 2514-1775 |
| Popis: | Objectives: To redefine criteria for high disease activity (HDA) in JIA, to establish HDA cut-off values for the 10-joint Juvenile Arthritis Disease Activity Score (JADAS10) and clinical JADAS10 (cJADAS10) and to describe the distribution of patients’ disease activity levels based on the JADAS cut-off values in the literature. Methods: Data on 305 treatment-naïve JIA patients were collected from nine paediatric units treating JIA. The median parameters of the JADAS were proposed to be the clinical criteria for HDA. The cut-off values were assessed by using two receiver operating characteristics curve–based methods. The patients were divided into disease activity levels based on currently used JADAS cut-off values. Results: We proposed new criteria for HDA. At least three of the following criteria must be satisfied in both disease courses: in oligoarthritis, two or more active joints, ESR above normal, physician global assessment (PGA) of disease activity ≥2 and parent/patient global assessment (PtGA) of well-being ≥2; in polyarthritis, six or more active joints, ESR above normal, PGA of overall disease activity ≥4 and PtGA of well-being ≥2. The HDA cut-off values for JADAS10 (cJADAS) were ≥6.7 (6.7) for oligoarticular and ≥15.3 (14.1) for polyarticular disease. The distribution of the disease activity levels based on the JADAS cut-off values in the literature varied markedly based on which cut-offs were used. Conclusion: New clinically derived criteria for HDA in JIA and both JADAS and cJADAS cut-off values for HDA were proposed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|