The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies

Autor: Prerna Malaney, Xiaorui Zhang, Marisa J.L. Aitken, Miguel Gallardo, Lauren E. Chan, Pedro Aguilar-Garrido, Maria Velasco-Estevez, Sean M. Post
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
lcsh:Immunologic diseases. Allergy
Lymphoma
B-Cell
RNA-binding protein
mouse model
Immunology
lymphoma
Review
MYC
Biology
Animals
Genetically Modified
Heterogeneous-Nuclear Ribonucleoprotein K
Proto-Oncogene Proteins c-myc
B-cell malignancies
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
medicine
Animals
Immunology and Allergy
Genetic Predisposition to Disease
B cell
Ribonucleoprotein
B-Lymphocytes
Eµ-Hnrnpk
Oncogene
hnRNP K
Cancer
medicine.disease
diffuse large B cell lymphoma
Up-Regulation
Lymphoma
Gene Expression Regulation
Neoplastic
Disease Models
Animal
Cell Transformation
Neoplastic
Phenotype
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cancer research
lcsh:RC581-607
Diffuse large B-cell lymphoma
Zdroj: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
ISSN: 1664-3224
Popis: B-cell lymphomas are one of the most biologically and molecularly heterogeneous group of malignancies. The inherent complexity of this cancer subtype necessitates the development of appropriate animal model systems to characterize the disease with the ultimate objective of identifying effective therapies. In this article, we discuss a new driver of B-cell lymphomas – hnRNP K (heterogenous nuclear ribonucleoprotein K)—an RNA-binding protein. We introduce the Eµ-Hnrnpk mouse model, a murine model characterized by hnRNP K overexpression in B cells, which develops B-cell lymphomas with high penetrance. Molecular analysis of the disease developed in this model reveals an upregulation of the c-Myc oncogene via post-transcriptional and translational mechanisms underscoring the impact of non-genomic MYC activation in B-cell lymphomas. Finally, the transplantability of the disease developed in Eµ-Hnrnpk mice makes it a valuable pre-clinical platform for the assessment of novel therapeutics.
Databáze: OpenAIRE
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