Deleterious Effect of Prednisolone in HBsAg-positive Chronic Active Hepatitis
| Autor: | Kui Chun Lam, Ching Lung Lai, R. P. Ng, Christian Trepo, P. C. Wu |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty HBsAg Globulin Prednisolone Remission Spontaneous Placebo Gastroenterology Hepatitis Random Allocation Antigen Internal medicine medicine Humans Aspartate Aminotransferases Prospective Studies Clinical Trials as Topic Hepatitis B Surface Antigens biology business.industry Mortality rate Alanine Transaminase Bilirubin General Medicine Middle Aged Hepatitis B medicine.disease Endocrinology Chronic Disease biology.protein Female Serum Globulins business medicine.drug |
| Zdroj: | New England Journal of Medicine. 304:380-386 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm198102123040702 |
| Popis: | To study the efficacy of corticosteroids in chronic active hepatitis (CAH) positive for hepatitis B surface antigen (HBsAg), we pair-randomized 51 patients to receive either 15 to 20 mg of prednisolone per day or a placebo. After initial remission, the maintenance dosage of prednisolone was 10 mg per day, and the patients were prospectively followed for up to 3 1/2 years. Prednisolone decreased serum bilirubin (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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