Effect of maternal immunisation with multivalent vaccines containing inactivated poliovirus vaccine (IPV) on infant IPV immune response: A phase 4, multi-centre randomised trial

Autor:	Nicholas C Grassly, Nick Andrews, Gillian Cooper, Laura Stephens, Pauline Waight, Christine E Jones, Paul T Heath, Anna Calvert, Jo Southern, Javier Martin, Elizabeth Miller
Rok vydání:	2023
Předmět:	Infectious Diseases General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health Molecular Medicine
Zdroj:	Vaccine. 41:1299-1302
ISSN:	0264-410X
DOI:	10.1016/j.vaccine.2023.01.035
Popis:	Multivalent diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine (DTaP/IPV) has been offered to pregnant women in the United Kingdom since 2012. To assess the impact of maternal DTaP/IPV immunisation on the infant immune response to IPV, we measured poliovirus-specific neutralising antibodies at 2, 5 and 13 months of age in a randomised, phase 4 study of Repevax or Boostrix/IPV in pregnancy and in a non-randomised group born to women not given DTaP/IPV in pregnancy. Infants whose mothers received DTaP/IPV were less likely to seroconvert after three IPV doses than those whose mothers did not receive DTaP/IPV. At 13 months of age, 63/110 (57.2 %), 46/108 (42.6 %) and 40/108 (37.0 %) were seropositive to types 1 to 3, compared with 20/22 (90.9 %), 20/22 (90.9 %) and 14/20 (70.0 %) (p-values 0.003
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0ab328826e1aa941abe773ad19fcac https://doi.org/10.1016/j.vaccine.2023.01.035 Zobrazit plný text záznamu Full Text from ScienceDirect