Inhibitors of antibiotic efflux pump in resistant Enterobacter aerogenes strains
| Autor: | Annie Eyraud, Monique Malléa, Jean-Marie Pagès, Jacqueline Chevalier |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Time Factors
biology Membrane permeability medicine.drug_class Chemistry Chloramphenicol Antibiotics Biophysics Enterobacter aerogenes Cell Biology biology.organism_classification Biochemistry Anti-Bacterial Agents Microbiology Multiple drug resistance Antibiotic resistance medicine Efflux Peptides Molecular Biology Intracellular medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 293:1370-1373 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(02)00404-7 |
| Popis: | Enterobacter aerogenes, a nosocomial pathogen, is frequently exhibiting multidrug resistance mechanisms associated with a change in membrane permeability. In clinical isolates, active efflux plays a prominent role in antibiotic resistance. We report here the effect of three unrelated compounds that are able to restore a noticeable antibiotic susceptibility to resistant strains. The targeting of various parameters which contribute to the efficacy of the efflux mechanism, such as energy, flux selectivity, or functional assembly of the membrane complex, increases the intracellular chloramphenicol concentration in resistant isolates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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