Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis - a cross-sectional study of long-term disease
| Autor: | Berit Flatø, Henriette S. Marstein, Trond Mogens Aaløkken, Ivar Sjaastad, May Britt Lund, Thomas Schwartz, Helga Sanner |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Vital capacity High-resolution computed tomography Adolescent Vital Capacity Gastroenterology Dermatomyositis Pulmonary function testing Young Adult Rheumatology Internal medicine Diffusing capacity medicine Humans Pharmacology (medical) Lung volumes Child Lung Juvenile dermatomyositis medicine.diagnostic_test business.industry Interstitial lung disease Middle Aged medicine.disease Respiratory Function Tests medicine.anatomical_structure Cross-Sectional Studies Cytokines Female business Lung Diseases Interstitial Tomography X-Ray Computed |
| Zdroj: | Rheumatology (Oxford, England). 59(8) |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | ObjectivesTo examine associations between cytokines and pulmonary involvement in patients with medium- to long-term JDM.MethodsIn a cross-sectional study, 58 patients examined median (range) 16.8 (6.6–27.0) years after symptom onset were stratified in inactive (JDM-inactive) and active (JDM-active) disease (updated PRINTO criteria); 56 age/sex matched controls were included. Twenty-nine cytokines (in serum) were analysed (Luminex technology/ELISA). Pulmonary function test included forced vital capacity, total lung capacity (TLC) and diffusing capacity for carbon monoxide reported as % of predicted and low forced vital capacity/TLC/diffusing capacity for carbon monoxide. In patients, the presence of clinical pulmonary damage was assessed and high resolution computed tomography scans were scored for interstitial lung disease, chest wall calcinosis and airways disease.ResultsMedian age of patients was 21 (7–55) years, 59% were female and 36% inactive. In JDM-active and all patients, higher MCP-1, IP-10 and eotaxin correlated with high-resolution computed tomography findings (rs 0.34–0.61; P < 0.05). MCP-1 and eotaxin correlated with pulmonary damage in JDM-active and all patients (rs 0.41–0.49; P < 0.01). Higher TGF-β1 and PDGF (growth factors) were associated with lower lung volumes (forced vital capacity/TLC measures) in all patients; PDGF in JDM-active and TGF-β1 in JDM-inactive patients. IP-10 correlated with TLC% in JDM-active patients. No associations between cytokines and pulmonary function test were found in controls.ConclusionsIn JDM, we found a novel association (not previously described in myositis) between eotaxin and pulmonary involvement; we have previously shown an association between eotaxin and cardiac dysfunction. The associations between IP-10/growth factors/MCP-1 and pulmonary involvement are novel in JDM and were mostly seen in JDM-active patients. |
| Databáze: | OpenAIRE |
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