Age and geographic patterns of Plasmodium falciparum malaria infection in a representative sample of children living in Burkitt lymphoma-endemic areas of northern Uganda
| Autor: | Marlena Maziarz, Isaac Otim, Patrick Kerchan, Samuel Kirimunda, Robert J. Biggar, Benjamin Emmanuel, Tobias Kinyera, James J. Goedert, Moses M. Joloba, Paul Kagwa, Steven J. Reynolds, Ismail D. Legason, Hadijah Nabalende, Andrew W. Bergen, Ambrose Talisuna, Martin D. Ogwang, Sam M. Mbulaiteye, Ruth M. Pfeiffer, Kishor Bhatia |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endemic Diseases Epidemiology 030231 tropical medicine Plasmodium falciparum Indoor residual spraying Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine parasitic diseases medicine Prevalence Humans Uganda Risk factor Malaria Falciparum Child Non-Hodgkin lymphoma Rapid diagnostic test biology business.industry Diagnostic Tests Routine Research Infant Newborn Burkitt lymphoma Infant Odds ratio medicine.disease biology.organism_classification Malaria Infectious Diseases 030220 oncology & carcinogenesis Child Preschool Immunology Tropical medicine Africa Parasitology Female business Demography |
| Zdroj: | Malaria Journal |
| ISSN: | 1475-2875 |
| Popis: | Background Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL-age children in populations where both diseases are endemic. To obtain accurate current data, patterns of asymptomatic malaria were investigated in northern Uganda, where BL is endemic. Methods Between 2011 and 2015, 1150 apparently healthy children under 15 years old were sampled from 100 villages in northern Uganda using a stratified, multi-stage, cluster survey design. Falciparum malaria prevalence (pfPR) was assessed by questionnaire, rapid diagnostic test (RDT) and thick film microscopy (TFM). Weighted pfPR and unadjusted and adjusted associations of prevalence with covariates were calculated using logistic models and survey methods. Results Based on 1143 children successfully tested, weighted pfPR was 54.8% by RDT and 43.4% by TFM. RDT sensitivity and specificity were 97.5 and 77.8%, respectively, as compared to TFM, because RDT detect malaria antigens, which persist in peripheral blood after clinical malaria, thus results based on RDT are reported. Weighted pfPR increased from 40% in children aged under 2 years to 61.8% in children aged 6–8 years (odds ratio 2.42, 95% confidence interval (CI) 1.26–4.65), then fell slightly to 49% in those aged 12–15 years. Geometric mean parasite density was 1805.5 parasites/µL (95% CI 1344.6–2424.3) among TFM-positive participants, and it was higher in children aged |
| Databáze: | OpenAIRE |
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