Does preoperative administration of allopurinol protect the lungs from ischemia-reperfusion injury occuring during cardiopulmonary bypass?
| Autor: | J B Celik, Z I Gormus, N Gormus, N Ergene, Abdulkerim Kasim Baltaci |
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| Přispěvatelé: | Selçuk Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Economics and Econometrics
ischemia-reperfusion injury Ischemia Allopurinol Lung injury allopurinol Pulmonary function testing law.invention lung Coronary artery disease law Preoperative Care Materials Chemistry Media Technology Cardiopulmonary bypass medicine Humans Intraoperative Complications business.industry Forestry Middle Aged medicine.disease medicine.anatomical_structure Reperfusion Injury Anesthesia business cardiopulmonary bypass Reperfusion injury medicine.drug Artery |
| Popis: | WOS: 000331063100003 PubMed: 24156678 Background: It is investigated whether preoperative allopurinol administration protects lung injury induced by cardiopulmonary bypass (CPB). Methods: Sixty patients with coronary artery disease who need elective coronary artery bypass grafting operations by using CPB were taken into this study. They were divided into two groups; control and allopurinol. Allopurinol (300 mg/day) was administered to the latter group during the preoperative period of 5 days. Standard CPB procedures were used in all cases. Blood was sampled for TNF-alpha, IL-6, IL-8, IL-10 before anesthesia (T0), after anesthesia and before skin incision (T1), before CPB (T2), after aortic declamping (T3), at the end of CPB (T4), 6 hours after operation (T5), 12 hours after operation (T6), and 24 hours after operation (T7). Pulmonary function test (PFT) was performed before and following the 6th day of operation. Results: TNF-alpha, IL-6, IL-8 increased in both groups at T3, T4, T5 and T6 compared to control (p |
| Databáze: | OpenAIRE |
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