Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma
| Autor: | Lei Wang, Dong Yang, Ying-Hou Wang, Xi Li, Hong-Ming Gao, Jun-Yuan Lv, Shi-Jie Xin |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Pathology Cancer Research Lymphoma Receptor tyrosine kinase-like orphan receptor Gene Expression Kaplan-Meier Estimate Receptor Tyrosine Kinase-like Orphan Receptors Wnt-5a Protein Pathogenesis 03 medical and health sciences Thyroid lymphoma Internal medicine Cell Line Tumor Medicine Humans Clinical significance Neoplasm Invasiveness Thyroid Neoplasms Pathological Ror2 Aged Neoplasm Staging Retrospective Studies business.industry General Medicine Wnt5a Middle Aged medicine.disease Primary thyroid lymphoma Prognosis Immunohistochemistry Tumor Burden body regions 030104 developmental biology embryonic structures Disease Progression Female sense organs business Lymphocytic Thyroiditis Research Article |
| Zdroj: | Tumour Biology |
| ISSN: | 1010-4283 |
| DOI: | 10.1007/s13277-015-4471-2 |
| Popis: | Primary thyroid lymphoma (PTL) is a rare malignant thyroid tumor; its pathogenesis is closely related to chronic lymphocytic thyroiditis. The different pathological subtypes and stages of PTL have distinct clinical characteristics and prognosis, but the specific reasons are not clear. Wnt5a is a representative protein of non-canonical Wnt signaling. It plays an important role in many different types of tumors. This study is to explore the changes of Wnt5a and its receptor Ror2 in PTL development process and the clinical significance of their represent. We collected 22 PTL patient tumor specimens and clinical data. We observed the expression of Wnt5a and Ror2 in PTL tumor tissues by immunohistochemistry. Wnt5a was expressed positively in 12 (54.5 %) cases, and Ror2 was expressed positively in 18 (81.8 %) cases. The expression of Wnt5a had a significant difference in different pathological subtypes of PTL (P |
| Databáze: | OpenAIRE |
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