Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association
| Autor: | Caroline Hoffmann, Rabie Chelbi, François-Xavier Danlos, Solana G. Alculumbre, Vassili Soumelis, Salvatore Raieli |
|---|---|
| Přispěvatelé: | Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
T cell [SDV]Life Sciences [q-bio] Population Cell macromolecular substances Biology medicine.disease_cause Autoimmunity Autoimmune Diseases 03 medical and health sciences 0302 clinical medicine Immune system Interferon medicine Hypersensitivity Humans education education.field_of_study hemic and immune systems Cell Biology Dendritic Cells Acquired immune system 3. Good health 030104 developmental biology medicine.anatomical_structure Immunology Immunotherapy 030217 neurology & neurosurgery Function (biology) Developmental Biology medicine.drug |
| Zdroj: | Seminars in Cell and Developmental Biology Seminars in Cell and Developmental Biology, Elsevier, 2019, 86, pp.24-35. ⟨10.1016/j.semcdb.2018.02.014⟩ |
| ISSN: | 1084-9521 1096-3634 |
| Popis: | Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer. We discuss recent advances in the field of pDC biology and their implication for future studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect