Therapeutic application of multipotent stem cells
| Autor: | Jan Stenvang, Hossein Salehi, Abdullah Moridikia, Mahmoud Reza Jaafari, Aria Masoudifar, Sara Nazari, Laleh Shiri Sichani, Hamid Reza Mirzaei, Javid Sadri Nahand, Amirhossein Sahebkar, Hamed Mirzaei |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell specific Clinical Trials as Topic Physiology Multipotent Stem Cells Clinical Biochemistry Clinical uses of mesenchymal stem cells Cell Separation Cell Biology Biology Cell biology Endothelial stem cell Cell therapy 03 medical and health sciences 030104 developmental biology Multipotent Stem Cell Cancer stem cell Neoplasms Immunology Cell separation Animals Humans Stem cell Stem Cell Transplantation |
| Zdroj: | Journal of Cellular Physiology. 233:2815-2823 |
| ISSN: | 0021-9541 |
| Popis: | Cell therapy is an emerging fields in the treatment of various diseases such as cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool for cell therapy. Multipotent stem cells are an important class of stem cells which have the ability to self-renew through dividing and developing into multiple specific cell types in a specific tissue or organ. These cells are capable to activate or inhibit a sequence of cellular and molecular pathways leading to anti-inflammatory and anti-apoptotic effects which might contribute to the treatment of various diseases. It has been showed that multipotent stem cells exert their therapeutic effects via inhibition/activation of a sequence of cellular and molecular pathways. Although the advantages of multipotent stem cells are numerous, further investigation is still necessary to clarify the biology and safety of these cells before they could be considered as a potential treatment for different types of diseases. This review summarizes different features of multipotent stem cells including isolation, differentiation, and therapeutic applications. |
| Databáze: | OpenAIRE |
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