Histological and histomorphometric studies on the cerebellar cortex and silver stained nucleolus organizer regions of Purkinje neurons in chronic morphine-treated rats
| Autor: | Ahmet Salbacak, İlhami Çelik, Muzaffer Şeker |
|---|---|
| Přispěvatelé: | Selçuk Üniversitesi |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty General Veterinary Nucleolus morphine Biology Purkinje neurone Rat Cerebellum 03 medical and health sciences 0302 clinical medicine Cerebellar cortex Morphine medicine 030101 anatomy & morphology rat cerebellum Morphine analgesia 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Veterinarski arhiv. 88:75-88 |
| ISSN: | 1331-8055 0372-5480 |
| DOI: | 10.24099/vet.arhiv.160902a |
| Popis: | WOS: 000425136100006 The effects of chronic morphine administration on the rat cerebellum and silver stained nucleolus organizer regions in Purkinje cells were investigated by means of histological, histochemical and histometrical techniques. Thirty-two young (30-32 days of age) Wistar rats (equal numbers of both genders) were randomly divided into 2 groups, as control and morphine-treated, each having equal numbers of both genders, a total of 16 animals. The control animals were injected subcutaneously with 1mL/kg physiological saline, and the morphine-treated rats received 5 mg/kg morphine hydrochloride subcutaneously at daily intervals for 30 days. The thickness of the molecular and granular layers of the cerebellum, the diameters of the nuclei and nucleoli of cerebellar Purkinje neurones, and the number and size of the silver staining nucleolus organizer regions of the Purkinje cell nuclei were determined histomorphometrically. The morphine administration caused slight histological changes in the cerebellum. The molecular layer thickness of the cerebellum was significantly (P |
| Databáze: | OpenAIRE |
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