MEDULLARY CARCINOMA OF BREAST: CLINICOPATHOLOGICAL STUDY
| Autor: | Pandurang G. Chougule, Sunil V Jagtap, Heena Pradeep Shah, Atul Beniwal, Suresh J Bhosale, Swati S. Jagtap |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty lcsh:R5-130.5 business.industry Medullary Subtype medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Histopathological Features Medullary carcinoma 030220 oncology & carcinogenesis Internal medicine Breast Cancer Medicine business lcsh:General works |
| Zdroj: | Journal of Evidence Based Medicine and Healthcare, Vol 3, Iss 45, Pp 2256-2260 (2016) |
| ISSN: | 2349-2570 2349-2562 |
| DOI: | 10.18410/jebmh/2016/500 |
| Popis: | AIM AND OBJECTIVES To study the clinical and histopathological features of medullary breast carcinoma (MBC) in rural population in Western Maharashtra. MATERIALS AND METHODS This is a retrospective, analytic study which is done at a tertiary care hospital from March 2010 to April 2016 for a period of 6 years. RESULTS Total of 241 consecutive cases of breast malignancy surgically operated for mastectomy or modified radical mastectomy were studied. From these 241 cases, 11 were reported as medullary carcinoma (constitute 4.56%). From these 11 cases, 10 cases were of typical medullary breast while 1 case was of atypical medullary breast carcinoma was noted. Each case was studied for clinical, morphological, radiological and immunohistochemistry (IHC) findings. For typical medullary carcinoma, the age range in present study was 33 to 55 years with a mean age of 46.3 years. The common clinical presentation was painless lump in the breast with common location being upper outer quadrant. The size of the tumour ranged from 2.5 to 9 cm with a mean size of 5.6 cm. The axillary lymph nodes were involved in 4 (40%) cases. The ER, PR and HER-2 were found to be positive in 10%, 10% and 20% respectively. Triple negative cases were 70%. CONCLUSION The clinicopathological features of medullary breast carcinoma showed early disease stage, having high-grade histological features of tumour, more triple negativity for ER/PR/HER2 and low rate of nodal metastasis. |
| Databáze: | OpenAIRE |
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