The Effect of Quinidine on Digoxin Kinetics in Cardiac Patients
| Autor: | Steffen Hvidt, Knud Erik Pedersen, Jens Hastrup |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Quinidine
Digoxin Heart Diseases Urinary system Pharmacology Kidney Excretion chemistry.chemical_compound Pharmacokinetics polycyclic compounds Internal Medicine Humans Medicine Drug Interactions cardiovascular diseases Aged Creatinine business.industry digestive oral and skin physiology Middle Aged carbohydrates (lipids) Kinetics chemistry Renal physiology business circulatory and respiratory physiology medicine.drug Clearance |
| Zdroj: | Acta Medica Scandinavica. 207:291-295 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1980.tb09723.x |
| Popis: | The pharmacokinetics of digoxin was studied in 11 subjects before and during quinidine treatment. Renal clearances of digoxin and creatinine were calculated from plasma concentrations and urinary excretions of digoxin and creatinine in subjects on long-term digoxin treatment. The investigations were repeated in the same subjects during administration of quinidine. Renal clearance of digoxin decreased, while plasma concentration of digoxin and renal excretion of digoxin increased in the presence of quinidine, indicating substantial changes of digoxin kinetics, induced by quinidine. The reduction in renal clearance of digoxin may be due to a specific inhibition of tubular secretion of digoxin. The considerable rise of the plasma digoxin level and the increased excretion of digoxin support the assumption of a major extrarenal mechanism of interaction. |
| Databáze: | OpenAIRE |
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