Comparison of the Serum Levels of Interferon-α in the Patients With Crimean-Congo Hemorrhagic Fever Based on Disease Severity
| Autor: | Nahid Sepehri Rad, Masoud Salehi, Alireza Noori Jangi, Masoume Noori Jangi, Farshid Fathi, Maliheh Metanat, Mehdi Noori Jangi, Anita Ale Nabi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Disseminated intravascular coagulation
Crimean–Congo hemorrhagic fever medicine.medical_specialty lcsh:R5-920 business.industry Serum Interferon-α medicine.disease Gastroenterology Disease severity Internal medicine Interferon α Immunology medicine South east Fatal disease Viral rna business Positive serology Crimean-Congo Hemorrhagic fever lcsh:Medicine (General) |
| Zdroj: | International Journal of Basic Science in Medicine, Vol 1, Iss 2, Pp 58-62 (2016) |
| Popis: | Introduction: Crimean-Congo hemorrhagic fever (CCHF) is an acute viral and potentially fatal disease that is endemic in the south east of Iran, especially Sistan and Baluchestan. This study aimed to measure the serum levels of interferon-[1]r (IFN-[1]r) in the patients with CCHF, considering the disseminated intravascular coagulation (DIC) severity. The second aim was to determine the correlation between the serum levels of IFN-[1]r and DIC severity using the guidance of diagnosis and treatment of the CCHF. Methods: Thirty-seven patients with CCHF were studied. The diagnosis was made, based on the detection of viral RNA by real time-polymerase chain reaction (RT-PCR) and by positive serology. These patients, based on the severity of DIC, were divided into two groups. The serum levels of IFN-[1]r were measured by the enzyme-linked immunosorbent assay (ELISA) method and compared between these two groups. Data analysis was performed using the SPSS 20.0 and non-parametric statistical tests were used for analyses. Results: The mean serum levels of IFN-[1]r were lower in the patients with CCHF on the rst day compared to the fth day of admission (P < 0.008). There was a signicant relationship between the serum levels of IFN-[1]r and DIC severity, as the level of IFN-[1]r was lower in the patients with overt DIC (P < 0.001). The serum level of IFN-[1]r in the patients with the overt DIC was 1.04 pg/dL with 90% specicity and 88% sensitivity. Conclusion: The serum levels of IFN-[1]r were lower in the patients with severe CCHF, and their evaluation may be used as a marker for the diagnosis of disease severity. |
| Databáze: | OpenAIRE |
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