Reduction of Invasive Aspergillosis Incidence among Immunocompromised Patients after Control of Environmental Exposure
| Autor: | Mauricette Michallet, Stéphane Picot, Philippe Vanhems, Anne C. M. Thiébaut, Marie-Antoinette Piens, Franck-Emmanuel Nicolini, Xavier Thomas, Marie-Christine Nicolle, Thomas Bénet |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Isolation (health care) law.invention Immunocompromised Host law Intensive care Epidemiology Air treatment medicine Aspergillosis Humans Hospital Design and Construction Cross Infection Infection Control business.industry Incidence Incidence (epidemiology) Environmental Exposure Hematology Environmental exposure Middle Aged Intensive care unit Surgery Intensive Care Units Infectious Diseases Emergency medicine Female France Relocation business |
| Zdroj: | Clinical Infectious Diseases. 45:682-686 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/521378 |
| Popis: | Background The objective of the study was to assess the impact of the relocation of an adult hematological intensive care unit on invasive aspergillosis (IA) incidence. Methods A quasi-experimental study, including a control group and an intervention group that both underwent pretest and posttest evaluations, was conducted in the 3 adult hematological intensive care units (each composed of 14 single rooms) in a university hospital from 14 April 2005 through 1 February 2006. One of these units was relocated from the main building to an adjoining modular construction. In this unit, 4 rooms were equipped with laminar airflow before relocation; all rooms were equipped with positive pressure isolation after relocation. The 2 other units (control group), each containing 8 rooms with laminar airflow, did not undergo environmental modification. The diagnostic criteria for IA were based on the criteria of the European Organization for Research and Treatment of Cancer. Results In total, 356 hospitalized patients were included. Of the 21 cases of IA, 18 were nosocomial, and 3 were of undetermined origin. In the relocated unit, the incidence of IA decreased from 13.2% (9 patients) before relocation to 1.6% (1 patient) after relocation (P=.018). Eight of the 9 patients with IA before relocation stayed in rooms without specific air treatment. The rate of IA did not change in the control group. Patient characteristics were similar in each unit before and after relocation. Conclusion We detected a straightforward association between environmental modification and decreased IA incidence, which emphasizes the use of an environmental strategy, including high-efficiency air filtration, in the prevention of IA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|