Neurophysiological impairments in multiple sclerosis - central and peripheral motor pathways

Autor: Inge Zijdewind, Sepehr Mamoei, Henrik Boye Jensen, Ulrik Dalgas, Egon Stenager, Lars G. Hvid
Přispěvatelé: Movement Disorder (MD)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
LOWER-LIMB
medicine.medical_treatment
DIAGNOSTIC-CRITERIA
Central nervous system
Neural Conduction
Electromyography
multiple sclerosis
FATIGUE
Efferent Pathways
03 medical and health sciences
MUSCLE STRENGTH
0302 clinical medicine
Physical medicine and rehabilitation
peripheral nervous system
Electroneuronography
medicine
EVOKED-POTENTIALS
FIBER SIZE
Humans
030212 general & internal medicine
neuromuscular function
Tibial nerve
PERCEPTION
medicine.diagnostic_test
business.industry
Multiple sclerosis
motor function
MUSCULAR EFFORT
General Medicine
Middle Aged
medicine.disease
Evoked Potentials
Motor
central nervous system
Compound muscle action potential
Transcranial magnetic stimulation
medicine.anatomical_structure
Neurology
Peripheral nervous system
EXCITABILITY
NEURAL DRIVE
Female
Neurology (clinical)
neurophysiology
business
030217 neurology & neurosurgery
Zdroj: Mamoei, S, Hvid, L G, Boye Jensen, H, Zijdewind, I, Stenager, E & Dalgas, U 2020, ' Neurophysiological impairments in multiple sclerosis : central and peripheral motor pathways ', Acta Neurologica Scandinavica, vol. 142, no. 5, pp. 401-417 . https://doi.org/10.1111/ane.13289
Acta neurologica Scandinavica, 142(5), 401-417. Wiley
Mamoei, S, Hvid, L G, Boye Jensen, H, Zijdewind, I, Stenager, E & Dalgas, U 2020, ' Neurophysiological impairments in multiple sclerosis-Central and peripheral motor pathways ', Acta Neurologica Scandinavica. Supplementum, vol. 142, no. 5, pp. 401-417 . https://doi.org/10.1111/ane.13289
ISSN: 1600-0404
0001-6314
DOI: 10.1111/ane.13289
Popis: A systematic review of the literature was conducted comparing neurophysiological outcomes in persons with multiple sclerosis (PwMS) to healthy controls (HC), in studies of the central nervous system (CNS) function comprising motor evoked potentials (MEP) elicited by transcranial magnetic stimulation (TMS) and in studies of the peripheral nervous system (PNS) function comprising electroneuronography (ENG) outcomes elicited by peripheral nerve stimulation. Studies comparing neuromuscular function, assessed during maximal voluntary contraction (MVC) of muscle, were included if they reported muscle strength along with muscle activation by use of electromyography (EMG) and/or interpolated twitch technique (ITT). Studies investigating CNS function showed prolonged central motor conduction times, asymmetry of nerve conduction motor pathways, and prolonged latencies in PwMS when compared to HC. Resting motor threshold, amplitude, and cortical silent periods showed conflicting results. CNS findings generally correlated with disabilities. Studies of PNS function showed near significant prolongation in motor latency of the median nerve, reduced nerve conduction velocities in the tibial and peroneal nerves, and decreased compound muscle action potential amplitudes of the tibial nerve in PwMS. ENG findings did not correlate with clinical severity of disabilities. Studies of neuromuscular function showed lower voluntary muscle activation and increased central fatigue in PwMS, whereas EMG showed divergent muscle activation (ie, EMG amplitude) during MVC. When comparing the existing literature on neurophysiological motor examinations in PwMS and HC, consistent and substantial impairments of CNS function were seen in PwMS, whereas impairments of the PNS were less pronounced and inconsistent. In addition, impairments in muscle activation were observed in PwMS.
Databáze: OpenAIRE
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