Reporting Two Fatalities Associated with the Use of 4-Methylethcathinone (4-MEC) and a Review of the Literature
| Autor: | Peter D. Maskell, Paul R. Smith, K. West, Stephen R. Morley, Sharon Hamilton, R. Cole |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Cathinone Health Toxicology and Mutagenesis Metabolite Venlafaxine Propranolol Pharmacology Toxicology 01 natural sciences Analytical Chemistry Forensic Toxicology Young Adult 03 medical and health sciences chemistry.chemical_compound Fatal Outcome 0302 clinical medicine medicine Humans Environmental Chemistry 030216 legal & forensic medicine Propiophenones Chemical Health and Safety business.industry Amphetamines 010401 analytical chemistry Middle Aged 0104 chemical sciences chemistry Toxicity 4-Methylethcathinone Drug Overdose business Diazepam Quantitative analysis (chemistry) medicine.drug |
| Zdroj: | Journal of Analytical Toxicology. 40:553-560 |
| ISSN: | 1945-2403 0146-4760 |
| DOI: | 10.1093/jat/bkw061 |
| Popis: | We report two fatalities that are related to the cathinone 4-methylethcathinone (4-MEC) and review the current knowledge of 4-MEC. Qualitative and quantitative analysis of 4-MEC was performed by validated high performance liquid chromatography-tandem mass spectrometry methods. In the first case a 22-year-old male died in hospital following collapse and seizures after using 4-MEC. Toxicological analysis of postmortem femoral blood revealed the presence of 4-MEC (0.167 mg/L), ethanol (27 mg/100 mL) and paracetamol (5 mg/L). Death was attributed solely to 4-MEC toxicity. The second case involved a 54-year-old man found with a taped plastic bag over his head. Toxicological analysis of postmortem femoral blood revealed the presence of 4-MEC (1.73 mg/L) along with ethanol (229 mg/100 mL), propranolol (0.036 mg/L), venlafaxine (0.284 mg/L) and its metabolite O-desmethylvenlafaxine (0.205 mg/L), and diazepam ( |
| Databáze: | OpenAIRE |
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